Pyometra | Causes, Symptoms & Treatment (new)


This condition is due to an accumulation of pus in the uterus and can occur after chronic endometritis or may result from the death of an embryo or fetus with subsequent infection by Corynobacterium pyogenes bacteria. The situation may persist undetected for some time and may be confused for pregnancy. 

Pyometra is a serious and potentially life-threatening infection of the uterus that causes it to fill with bacteria and pus. Many dogs with a pyometra have vaginal discharge and may feel very sick with a poor appetite, lethargy, vomiting and sometimes increased thirst or urination.


  • Hormonal changes and, most commonly, the bacteria E. coli that can ascend from the vagina into the uterus
  • Impairment of natural drainage of the cervix as a result of benign or malignant diseases

 Clinical Signs

  • Enlarged uterus.
  • Discharge of pus when the cow lies down.


  • Uterus palpataion by a veterinarian.
  • Uterus scan

Recommended Treatment

  • Treatment used by estrogens and oxytocin according to veterinary advice.
  • Surgery to remove the ovaries and uterus (spay)
  • Prostaglandin F2-alpha is the most commonly used medication to medically manage pyometra in dogs.


Dogs: The recommended dosage is 5 mg/lb of body weight twice a day.

Cats: The recommended dosage is 50 mg (5–10 mg/lb) once a day. Dosage should be continued for 5–7 days or 48 hours after all symptoms have subsided.

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